Profit and Drawback of Rehabilitative Therapy in Animal Models of Acute Ischemic Brain Injury
Sung-Rae Cho, MD, PhD1 Sun Hee Yim2 and Hyo Sun Kim2
1Department of Rehabilitation Medicine and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Korea, 2Clinical Research Center, Yonsei University Health System, Seoul, Korea
ABSTRACT
Neural stem/progenitor cells persist throughout the hippocampus and subventricular zone (SVZ) even in the adult brain. Rehabilitative therapy such as enriched environment (EE) and voluntary running exercise can induce neurogenesis in the neurogenic area. Neuronal recruitment into striatum, non-neurogenic region, from the SVZ might be also induced by EE in the living condition of huge cage, social interaction and objects such as toys, tunnels, nesting materials and running wheel. However, many researchers have shown different results on cell genesis and neurogenesis of the SVZ and striatum in the ischemic brain by EE and physical exercise. In addition, strenuous or forced rehabilitative training and early immobilization of sound upper extremity, constraint-induced therapy, can exacerbate ischemic brain damage during acute period. Therefore, it is necessary to find out appropriate time, duration and intensity of the rehabilitative therapy in order that the therapeutic strategy might be applicable for neural regeneration to various neurological diseases, i.e., ischemic stroke, cerebral palsy and other neurodegenerative diseases.
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